Abstract
Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an SNAr step. We detail specific steps for a gram-scale preparation of 2-((perfluoropyridin-4-yl)thio)benzo[d]thiazole 3 from mercaptobenzothiazole 1 and pentafluoropyridine 2.
Original language | English (US) |
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Pages (from-to) | 102043 |
Journal | STAR Protocols |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - Jan 19 2023 |
Bibliographical note
KAUST Repository Item: Exported on 2023-02-16Acknowledgements: The authors thank Shinje Miñoza (NSYSU) for review and editing the manuscript. C. -L.C. thanks the financial support from the National Science and Technology Council (Taiwan) Research College Student Research Scholarship (Award number 110CFA0800030). This work was supported by the National Science and Technology Council in Taiwan (MOST 111-2636-M-110-011).