A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an SNAr step

Cheng Lin Chan, Shao-Chi Lee, Hsuan Hung Liao

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2 Scopus citations

Abstract

Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an SNAr step. We detail specific steps for a gram-scale preparation of 2-((perfluoropyridin-4-yl)thio)benzo[d]thiazole 3 from mercaptobenzothiazole 1 and pentafluoropyridine 2.
Original languageEnglish (US)
Pages (from-to)102043
JournalSTAR Protocols
Volume4
Issue number1
DOIs
StatePublished - Jan 19 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-02-16
Acknowledgements: The authors thank Shinje Miñoza (NSYSU) for review and editing the manuscript. C. -L.C. thanks the financial support from the National Science and Technology Council (Taiwan) Research College Student Research Scholarship (Award number 110CFA0800030). This work was supported by the National Science and Technology Council in Taiwan (MOST 111-2636-M-110-011).

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