Abstract
The paramount relevance of protein phosphorylation in health and disease motivated us to gather several contributions from experts working in this area in order to portray the recent developments in the field. Our effort and the effort of 54 authors with their 12 contributions gave rise to this Research Topic, which represents a valuable forum where phosphorylation is discussed from different angles, including bioinformatics approaches and experimental methods that are currently used to decipher the complex mechanisms underlying this bewitching post-translational modification (PTM). The articles collected in this Research Topic illustrate very diverse aspects of phosphorylation, such as its biological effects and induced structural changes, the role of kinases and phosphatases as therapeutic targets, the use of phosphorylation profiles as biomarkers, how phosphorylation dys-regulation may cause disease, and more.
| Original language | English (US) |
|---|---|
| Journal | Frontiers in Genetics |
| Volume | 6 |
| Issue number | APR |
| DOIs | |
| State | Published - Apr 7 2015 |
| Externally published | Yes |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: AV acknowledges the King Abdullah University of Science and Technology (KAUST) Award n° KUK-I1-012-43 and AZ the French “Plan Cancer 2009–2013” program (Systems Biology call, A12171AS) and the A*MIDEX project (n° ANR-11-IDEX-0001-02) for financial support.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.