A novel synthesis of non-aggregated spinel nickel ferrite nanosheets for developing non-enzymatic reactive oxygen species sensor in biological samples

Kogularasu Sakthivel, Govindasamy Mani, Shen Ming Chen, Shih Hao Lin, Akilarasan Muthumariappan, Veerappan Mani

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Herein, the synthesis of novel non-aggregated spinel nickel ferrite, NiFe2O4 nanosheets (NiFe2O4 NSs) and its application towards the selective electrocatalytic reduction of hydrogen peroxide are described. Initially, NiFe2O4 NSs is synthesized by one-step hydrothermal approach, and numerous characterizations deliberately explain the compound's composition and structure. Finally, the NiFe2O4 NSs underwent direct non-enzymatic electrochemistry and succeeded, it as mimicking Horseradish Peroxidase properties. The significance of non-aggregated NiFe2O4 NSs together with good electrocatalytic properties leads the material to the platform for electrochemical sensors. Moreover, NiFe2O4 NSs is fabricated and validated as an enzyme-free biosensor for the sensitive detection of H2O2. The demonstrated sensor revealed excellent detection of H2O2 with the pico-molar detection limit (12.4 pM), and also it offered good analytical parameters with more extensive linear range and higher sensitivity. Likewise, the non-enzymatic biosensor annexes good durability, reproducibility, and selectivity towards the determination of H2O2. Due to the nourishing capacity of the prepared NiFe2O4 NSs, it is employed for the enzyme-free detection of H2O2 in human blood and rat brain serum samples.
Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalJournal of Electroanalytical Chemistry
Volume820
DOIs
StatePublished - Jul 1 2018
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-21

ASJC Scopus subject areas

  • General Chemical Engineering
  • Analytical Chemistry
  • Electrochemistry

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