A novel end-reactive dendron in the accelerated synthesis of carboxylate-terminated dendritic poly(ether-amides)

A novel end-reactive AB₄ dendron with four phenolic coupling sites and a benzyl alcohol functionality at the focal point has been prepared by a chemoselective amidation process that requires no functional group protection. The usefulness of the end-reactive dendron for the accelerated synthesis of dendritic polymers has been demonstrated in the preparation of several poly(amide-ether) dendritic macromolecules with carboxylate chain-ends. The new dendritic polymers have been characterized by NMR and MALDI mass spectrometry, size exclusion chromatography, and thermal analysis methods.