A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Arnab Pain; Britta C. Urban; Oscar Kai; Climent Casals-Pascual; Juma Shafi; Kevin Marsh; David J. Roberts

doi:10.1016/S0140-6736(00)04662-6

A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Arnab Pain, Britta C. Urban, Oscar Kai, Climent Casals-Pascual, Juma Shafi, Kevin Marsh, David J. Roberts^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

Original language	English (US)
Pages (from-to)	1502-1503
Number of pages	2
Journal	Lancet
Volume	357
Issue number	9267
DOIs	https://doi.org/10.1016/S0140-6736(00)04662-6
State	Published - May 12 2001
Externally published	Yes

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(00)04662-6

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title = "A non-sense mutation in Cd36 gene is associated with protection from severe malaria",

abstract = "We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.",

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T1 - A non-sense mutation in Cd36 gene is associated with protection from severe malaria

AU - Pain, Arnab

AU - Urban, Britta C.

AU - Kai, Oscar

AU - Casals-Pascual, Climent

AU - Shafi, Juma

AU - Marsh, Kevin

AU - Roberts, David J.

PY - 2001/5/12

Y1 - 2001/5/12

N2 - We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

AB - We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

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AN - SCOPUS:0035849284

SN - 0140-6736

VL - 357

SP - 1502

EP - 1503

JO - Lancet

JF - Lancet

IS - 9267

ER -

A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Abstract

ASJC Scopus subject areas

UN SDGs

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