A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction

David A. Evans*, Daniel Seidel, Magnus Rueping, Hon Wai Lam, Jared T. Shaw, C. Wade Downey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

492 Scopus citations


A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.

Original languageEnglish (US)
Pages (from-to)12692-12693
Number of pages2
JournalJournal of the American Chemical Society
Issue number42
StatePublished - Oct 22 2003
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction'. Together they form a unique fingerprint.

Cite this