A new approach for quantifying epigenetic landscapes.

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ChIP-Seq is a widespread experimental method for determining the global enrichment of chromatin modifications and genome-associated factors. Whereas it is straightforward to compare the relative genomic distribution of these epigenetic features, researchers have also made efforts to compare their signal strength using external references for normalization. New work now suggests that these "spike-ins" could lead to inaccurate conclusions due to intrinsic issues of the methodology and instead calls for new criteria of experimental reporting that may permit internal standardization when certain parameters are fulfilled.
Original languageEnglish (US)
Pages (from-to)15838-15839
Number of pages2
JournalThe Journal of biological chemistry
Issue number47
StatePublished - Nov 21 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-11-24


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