TY - JOUR
T1 - A Microfluidic Ion Pump for In Vivo Drug Delivery
AU - Uguz, Ilke
AU - Proctor, Christopher M.
AU - Curto, Vincenzo F.
AU - Pappa, Anna-Maria
AU - Donahue, Mary J.
AU - Ferro, Magali
AU - Owens, Róisín M.
AU - Khodagholy, Dion
AU - Inal, Sahika
AU - Malliaras, George G.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: I.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.
PY - 2017/5/15
Y1 - 2017/5/15
N2 - Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.
AB - Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.
UR - http://hdl.handle.net/10754/623783
UR - http://onlinelibrary.wiley.com/doi/10.1002/adma.201701217/full
UR - http://www.scopus.com/inward/record.url?scp=85019265122&partnerID=8YFLogxK
U2 - 10.1002/adma.201701217
DO - 10.1002/adma.201701217
M3 - Article
C2 - 28503731
SN - 0935-9648
VL - 29
SP - 1701217
JO - Advanced Materials
JF - Advanced Materials
IS - 27
ER -