A highly enantioselective Brønsted acid catalyzed reaction cascade

Magnus Rueping*, Andrey P. Antonchick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


(Chemical Equation Presented) One cat. is enough! A highly enantiose-lective reaction has been developed for the three-component reaction of an enamine with a vinyl ketone and a Hantszsch ester in which each of the six reaction steps is catalyzed by the same chiral Brønsted acid (see scheme). This reaction offers efficient access to tetrahydropyridines and azadecalinones from simple and readily available starting materials.

Original languageEnglish (US)
Pages (from-to)5836-5838
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number31
StatePublished - Jul 21 2008
Externally publishedYes


  • Michael reaction
  • Organocatalysis
  • Phosphates
  • Piperidines
  • Reductive amination

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


Dive into the research topics of 'A highly enantioselective Brønsted acid catalyzed reaction cascade'. Together they form a unique fingerprint.

Cite this