A flexible hydrophilic-modified graphene microprobe for neural and cardiac recording

Chang Hsiao Chen, Cheng Te Lin, Wei Lun Hsu, Yen Chung Chang, Shih Rung Yeh, Lain-Jong Li, Da Jeng Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


A graphene-based flexible microprobe developed by microelectromechanical system technology shows high resolution for the detection of electrophysiological signals from various bio-objects. The hydrophilization post-treatment using steam plasma was performed on the graphene surface to decrease the interfacial impedance between graphene and electrolyte, and thus improve the signal-to-noise ratio during neural and cardiac recording. The signal-to-noise ratio of the action potentials from axons of a crayfish measured by hydrophilic-modified graphene microprobe (27.8±4.0dB) is higher than that of untreated device (20.3±3.3dB). Also, the form of the QRS complex and T wave in the electrocardiogram of the zebrafish heart can be clearly distinguished using the modified device. The total measured noise levels of the overall stability of the system were 4.2μVrms (hydrophilic graphene) and 7.64μVrms (hydrophobic graphene). The graphene-based implant can be further used for in vivo, long-term recording and retina prosthesis. From the Clinical Editor: In this study a graphene-based flexible microprobe developed using microelectromechanical system technology was demonstrated to enable high resolution detection of electrophysiological signals, including EKG in zebrafish models. Both hydrophilic and hydrophobic graphene were studied, paving the way to potential future clinical applications of this new technology.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number5
StatePublished - Jul 1 2013


  • Electrocardiogram
  • Flexible microprobe
  • Graphene
  • Hydrophilization
  • Neural recording

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Molecular Medicine
  • General Materials Science
  • Pharmaceutical Science


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