A DIStinctively novel exoribonuclease that really likes U

Imed E. Gallouzi; Jeffrey Wilusz

doi:10.1038/emboj.2013.136

A DIStinctively novel exoribonuclease that really likes U

Imed E. Gallouzi, Jeffrey Wilusz

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as a major player in the 30-50 exonucleolytic decay of transcripts. Furthermore, they demonstrate a strong connection between terminal uridylation of the RNA substrate and enzymatic activity. © 2013 European Molecular Biology Organization.

Original language	English (US)
Pages (from-to)	1799-1801
Number of pages	3
Journal	EMBO Journal
Volume	32
Issue number	13
DOIs	https://doi.org/10.1038/emboj.2013.136
State	Published - Jul 3 2013
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2022-09-13

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
Molecular Biology
General Immunology and Microbiology

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10.1038/emboj.2013.136

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AB - Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as a major player in the 30-50 exonucleolytic decay of transcripts. Furthermore, they demonstrate a strong connection between terminal uridylation of the RNA substrate and enzymatic activity. © 2013 European Molecular Biology Organization.

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A DIStinctively novel exoribonuclease that really likes U

Abstract

Bibliographical note

ASJC Scopus subject areas

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