A DIStinctively novel exoribonuclease that really likes U

Imed E. Gallouzi, Jeffrey Wilusz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as a major player in the 30-50 exonucleolytic decay of transcripts. Furthermore, they demonstrate a strong connection between terminal uridylation of the RNA substrate and enzymatic activity. © 2013 European Molecular Biology Organization.
Original languageEnglish (US)
Pages (from-to)1799-1801
Number of pages3
JournalEMBO Journal
Issue number13
StatePublished - Jul 3 2013
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2022-09-13

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • General Immunology and Microbiology


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