Abstract
The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | D1230-D1234 |
| Number of pages | 1 |
| Journal | Nucleic Acids Research |
| Volume | 40 |
| Issue number | D1 |
| DOIs | |
| State | Published - Nov 10 2011 |
| Externally published | Yes |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43); FIRB Proteomica, Ministery of Health grant (Contract No. Onc_Ord 25/07); IIT SEED project. Funding for open access charge: King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.