A comparison of host response strategies to distinguish bacterial and viral infection

Melissa Ross; Ricardo Henao; Thomas W. Burke; Emily R. Ko; Micah T. McClain; Geoffrey S. Ginsburg; Christopher W. Woods; Ephraim L. Tsalik

doi:10.1371/journal.pone.0261385

A comparison of host response strategies to distinguish bacterial and viral infection

Melissa Ross, Ricardo Henao, Thomas W. Burke, Emily R. Ko, Micah T. McClain, Geoffrey S. Ginsburg, Christopher W. Woods, Ephraim L. Tsalik

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objectives Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI). Methods In this observational cohort study, procalcitonin, a 3-protein panel (CRP, IP-10, TRAIL), and a host gene expression mRNA panel were measured in 286 subjects with ARI from four emergency departments. Multinomial logistic regression and leave-one-out cross validation were used to evaluate the protein and mRNA tests. Results The mRNA panel performed better than alternative strategies to identify bacterial infection: AUC 0.93 vs. 0.83 for the protein panel and 0.84 for procalcitonin (P

Original language	English (US)
Journal	PloS one
Volume	16
Issue number	12 December
DOIs	https://doi.org/10.1371/journal.pone.0261385
State	Published - Dec 1 2021
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-02-15

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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title = "A comparison of host response strategies to distinguish bacterial and viral infection",

abstract = "Objectives Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI). Methods In this observational cohort study, procalcitonin, a 3-protein panel (CRP, IP-10, TRAIL), and a host gene expression mRNA panel were measured in 286 subjects with ARI from four emergency departments. Multinomial logistic regression and leave-one-out cross validation were used to evaluate the protein and mRNA tests. Results The mRNA panel performed better than alternative strategies to identify bacterial infection: AUC 0.93 vs. 0.83 for the protein panel and 0.84 for procalcitonin (P",

author = "Melissa Ross and Ricardo Henao and Burke, {Thomas W.} and Ko, {Emily R.} and McClain, {Micah T.} and Ginsburg, {Geoffrey S.} and Woods, {Christopher W.} and Tsalik, {Ephraim L.}",

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doi = "10.1371/journal.pone.0261385",

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T1 - A comparison of host response strategies to distinguish bacterial and viral infection

AU - Ross, Melissa

AU - Henao, Ricardo

AU - Burke, Thomas W.

AU - Ko, Emily R.

AU - McClain, Micah T.

AU - Ginsburg, Geoffrey S.

AU - Woods, Christopher W.

AU - Tsalik, Ephraim L.

N1 - Generated from Scopus record by KAUST IRTS on 2023-02-15

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Objectives Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI). Methods In this observational cohort study, procalcitonin, a 3-protein panel (CRP, IP-10, TRAIL), and a host gene expression mRNA panel were measured in 286 subjects with ARI from four emergency departments. Multinomial logistic regression and leave-one-out cross validation were used to evaluate the protein and mRNA tests. Results The mRNA panel performed better than alternative strategies to identify bacterial infection: AUC 0.93 vs. 0.83 for the protein panel and 0.84 for procalcitonin (P

AB - Objectives Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI). Methods In this observational cohort study, procalcitonin, a 3-protein panel (CRP, IP-10, TRAIL), and a host gene expression mRNA panel were measured in 286 subjects with ARI from four emergency departments. Multinomial logistic regression and leave-one-out cross validation were used to evaluate the protein and mRNA tests. Results The mRNA panel performed better than alternative strategies to identify bacterial infection: AUC 0.93 vs. 0.83 for the protein panel and 0.84 for procalcitonin (P

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A comparison of host response strategies to distinguish bacterial and viral infection

Abstract

Bibliographical note

ASJC Scopus subject areas

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