A Class of Effective of Decarboxylative Perfluoroalkylating Reagents: [(phen)2Cu](O2CRF)

Yangjie Huang, Manjaly John Ajitha, Kuo-Wei Huang, Zhongxing Zhang, Zhiqiang Weng

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


This article describes the invention of a class of effective reagents [(phen)2Cu](O2CRF) (1) for the decarboxylative perfluoroalkylation of aryl and heteroaryl halides. Treatment of the copper tert-butyloxide with phenanthroline ligands, with subsequent addition of perfluorocarboxylic acids afforded the air-stable copper(I) perfluorocarboxylato complexes 1. These complexes reacted with a variety of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies suggested that the coordination of the second phen ligand may reduce the energy barrier for the decarboxylation of perfluorocarboxylate to facilitate the perfluoroalkylation.
Original languageEnglish (US)
Pages (from-to)8468-8474
Number of pages7
JournalDalton Trans.
Issue number20
StatePublished - 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Financial support from the National Natural Science
Foundation of China (NSFC) (grant number 21372044), the
Research Fund for the Doctoral Program of Higher Education
of China (grant number 20123514110003), and Fuzhou
University (grant number 022494) is gratefully acknowledged.


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