A chemical approach to "rewire" neural progenitor cells

Min Zu Wu; Mo Li; Guang Hui Liu; Juan Carlos Izpisua Belmonte

doi:10.1038/cr.2014.51

A chemical approach to "rewire" neural progenitor cells

Min Zu Wu, Mo Li, Guang Hui Liu, Juan Carlos Izpisua Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.

Original language	English (US)
Pages (from-to)	641-642
Number of pages	2
Journal	Cell research
Volume	24
Issue number	6
DOIs	https://doi.org/10.1038/cr.2014.51
State	Published - Jun 2014
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2014.51

Cite this

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abstract = "Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.",

author = "Wu, {Min Zu} and Mo Li and Liu, {Guang Hui} and Belmonte, {Juan Carlos Izpisua}",

year = "2014",

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AB - Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.

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A chemical approach to "rewire" neural progenitor cells

Abstract

ASJC Scopus subject areas

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