A Blood-Based Molecular Clock for Biological Age Estimation

Ersilia Paparazzo, Silvana Geracitano, Vincenzo Lagani, Denise Bartolomeo, Mirella Aurora Aceto, Patrizia D’Aquila, Luigi Citrigno, Dina Bellizzi, Giuseppe Passarino, Alberto Montesanto

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In the last decade, extensive efforts have been made to identify biomarkers of biological age. DNA methylation levels of ELOVL fatty acid elongase 2 (ELOVL2) and the signal joint T-cell receptor rearrangement excision circles (sjTRECs) represent the most promising candidates. Although these two non-redundant biomarkers echo important biological aspects of the ageing process in humans, a well-validated molecular clock exploiting these powerful candidates has not yet been formulated. The present study aimed to develop a more accurate molecular clock in a sample of 194 Italian individuals by re-analyzing the previously obtained EVOLV2 methylation data together with the amount of sjTRECs in the same blood samples. The proposed model showed a high prediction accuracy both in younger individuals with an error of about 2.5 years and in older subjects where a relatively low error was observed if compared with those reported in previously published studies. In conclusion, an easy, cost-effective and reliable model to measure the individual rate and the quality of aging in human population has been proposed. Further studies are required to validate the model and to extend its use in an applicative context.
Original languageEnglish (US)
Pages (from-to)32
Issue number1
StatePublished - Dec 21 2022

Bibliographical note

KAUST Repository Item: Exported on 2023-01-13
Acknowledgements: The work has been made possible by the collaboration with the nursing homes of Sadel Spa, Sadel San Teodoro srl, Sadel CS srl, Casa di Cura Madonna dello Scoglio, AGI srl, Casa di Cura Villa del Rosario srl, Savelli Hospital srl, Casa di Cura Villa Ermelinda, in the frame of the agreement “Attività di Ricerca e Sviluppo Sperimentale: Tecnologie avanzate per l’indagine delle relazioni tra uomo ed ambienti di vita” with the University of Calabria.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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