A biocompatible method of decorporation: Bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood

Ling Wang; Zhimou Yang; Jinhao Gao; Kerning Xu; Hongwei Gu; Bei Zhang; Xixiang Zhang; Bing Xu

doi:10.1021/ja0651355

A biocompatible method of decorporation: Bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood

Ling Wang, Zhimou Yang, Jinhao Gao, Kerning Xu, Hongwei Gu, Bei Zhang, Xixiang Zhang, Bing Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

222 Scopus citations

Abstract

We report on the use of bisphosphonate to functionalize Fe₃O₄ magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe₃O₄-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.

Original language	English (US)
Pages (from-to)	13358-13359
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	41
DOIs	https://doi.org/10.1021/ja0651355
State	Published - Oct 18 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.",

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AU - Wang, Ling

AU - Yang, Zhimou

AU - Gao, Jinhao

AU - Xu, Kerning

AU - Gu, Hongwei

AU - Zhang, Bei

AU - Zhang, Xixiang

AU - Xu, Bing

PY - 2006/10/18

Y1 - 2006/10/18

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AB - We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.

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JF - Journal of the American Chemical Society

IS - 41

ER -

A biocompatible method of decorporation: Bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood

Abstract

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