A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction

Keyphrases

• HIV-1 Nef 100%
• Biophysical Assays 100%
• Triage 100%
• Treatment Regimen 50%
• Viral Pathogenicity 50%
• Host Factors 50%
• Resonance Energy 50%
• Resonance Energy Transfer 50%
• Time-resolved Fluorescence 50%
• Grating-based 50%
• Continual Improvement 50%
• Energy Resonance 50%
• Antiretroviral 50%
• Pathogenicity Factors 50%
• Drug Class 50%
• Cell Signaling Pathways 50%
• Adverse Drug Reaction 50%
• Fluorescence Resonance 50%

Chemistry

• High Throughput Screening 100%
• Protein Interaction 50%
• Resonance Energy 50%
• Fluorescence Resonance Energy Transfer 50%
• Label 50%
• Antiretroviral 50%

Pharmacology, Toxicology and Pharmaceutical Science

• HIV 100%
• High-Throughput Screening 33%
• Adverse Drug Reaction 33%
• Host Factor 33%
• Virus Virulence 33%
• Drug Resistance 33%