A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

Mark D. Preston; Susana Campino; Samuel A. Assefa; Diego F. Echeverry; Harold Ocholla; Alfred Amambua-Ngwa; Lindsay B. Stewart; David J. Conway; Steffen Borrmann; Pascal Michon; Issaka Zongo; Jean-Bosco Ouédraogo; Abdoulaye A. Djimde; Ogobara K. Doumbo; Francois Nosten; Arnab Pain; Teun Bousema; Chris J. Drakeley; Rick M. Fairhurst; Colin J. Sutherland; Cally Roper; Taane G. Clark

doi:10.1038/ncomms5052

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

Mark D. Preston, Susana Campino, Samuel A. Assefa, Diego F. Echeverry, Harold Ocholla, Alfred Amambua-Ngwa, Lindsay B. Stewart, David J. Conway, Steffen Borrmann, Pascal Michon, Issaka Zongo, Jean-Bosco Ouédraogo, Abdoulaye A. Djimde, Ogobara K. Doumbo, Francois Nosten, Arnab Pain, Teun Bousema, Chris J. Drakeley, Rick M. Fairhurst, Colin J. SutherlandCally Roper, Taane G. Clark

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (?92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. 2014 Macmillan Publishers Limited. All rights reserved.

Original language	English (US)
Journal	Nature Communications
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/ncomms5052
State	Published - Jun 13 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Chemistry
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncomms5052

https://repository.kaust.edu.sa/bitstream/10754/325324/1/Article-Nature_Com-A_barcode_-2014.pdf

Cite this

Preston, M. D., Campino, S., Assefa, S. A., Echeverry, D. F., Ocholla, H., Amambua-Ngwa, A., Stewart, L. B., Conway, D. J., Borrmann, S., Michon, P., Zongo, I., Ouédraogo, J.-B., Djimde, A. A., Doumbo, O. K., Nosten, F., Pain, A., Bousema, T., Drakeley, C. J., Fairhurst, R. M., ... Clark, T. G. (2014). A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains. Nature Communications, 5(1). https://doi.org/10.1038/ncomms5052

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title = "A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains",

abstract = "Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (?92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. 2014 Macmillan Publishers Limited. All rights reserved.",

author = "Preston, {Mark D.} and Susana Campino and Assefa, {Samuel A.} and Echeverry, {Diego F.} and Harold Ocholla and Alfred Amambua-Ngwa and Stewart, {Lindsay B.} and Conway, {David J.} and Steffen Borrmann and Pascal Michon and Issaka Zongo and Jean-Bosco Ou{\'e}draogo and Djimde, {Abdoulaye A.} and Doumbo, {Ogobara K.} and Francois Nosten and Arnab Pain and Teun Bousema and Drakeley, {Chris J.} and Fairhurst, {Rick M.} and Sutherland, {Colin J.} and Cally Roper and Clark, {Taane G.}",

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Preston, MD, Campino, S, Assefa, SA, Echeverry, DF, Ocholla, H, Amambua-Ngwa, A, Stewart, LB, Conway, DJ, Borrmann, S, Michon, P, Zongo, I, Ouédraogo, J-B, Djimde, AA, Doumbo, OK, Nosten, F, Pain, A, Bousema, T, Drakeley, CJ, Fairhurst, RM, Sutherland, CJ, Roper, C & Clark, TG 2014, 'A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains', Nature Communications, vol. 5, no. 1. https://doi.org/10.1038/ncomms5052

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T1 - A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

AU - Preston, Mark D.

AU - Campino, Susana

AU - Assefa, Samuel A.

AU - Echeverry, Diego F.

AU - Ocholla, Harold

AU - Amambua-Ngwa, Alfred

AU - Stewart, Lindsay B.

AU - Conway, David J.

AU - Borrmann, Steffen

AU - Michon, Pascal

AU - Zongo, Issaka

AU - Ouédraogo, Jean-Bosco

AU - Djimde, Abdoulaye A.

AU - Doumbo, Ogobara K.

AU - Nosten, Francois

AU - Pain, Arnab

AU - Bousema, Teun

AU - Drakeley, Chris J.

AU - Fairhurst, Rick M.

AU - Sutherland, Colin J.

AU - Roper, Cally

AU - Clark, Taane G.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2014/6/13

Y1 - 2014/6/13

N2 - Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (?92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. 2014 Macmillan Publishers Limited. All rights reserved.

AB - Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (?92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. 2014 Macmillan Publishers Limited. All rights reserved.

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DO - 10.1038/ncomms5052

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C2 - 24923250

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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