A balance between silencing foreign DNA and protecting self in Caenorhabditis elegans

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Unrestrained transposon mobilization threatens genome integrity. To survive, organisms have evolved silencing pathways capable of distinguishing self from non-self. This review emphasizes C. elegans genome defense with a particular emphasis on systems-level detection of foreign DNA and the balance between silencing and protective pathways. Abundant small RNAs (piRNAs and siRNAs), aberrant DNA structures (e.g., introns), and heterochromatin domains largely mediate silencing. For example, CRISPR-based manipulation of endogenous piRNAs has elucidated precise targeting rules and a novel, conserved role in tuning endogenous germline gene expression. Protective pathways are only just becoming clear: small RNA pathways (CSR-1), deamination of endogenous dsRNA, and a pervasive, embedded DNA watermark (PATCs) can all counteract silencing to protect endogenous genes.
Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalCurrent Opinion in Systems Biology
StatePublished - Sep 16 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: I would like to thank Darryl Conte, Carolyn Phillips, and an anonymous reviewer for helpful suggestions on the manuscript. Funding: This work was supported by KAUST's internal research support.


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