6.13 C-C Bond Formation: Cascade or Domino Reaction

M. Rueping*, I. Atodiresei

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


Over the past few years, the field of organocatalyzed domino reactions, with particular focus on enantioselective C-C bond forming reactions, has experienced a rapid and impressive development and is now offering a complementary approach to metal and biocatalyzed cascade reactions. Organocatalytic domino reactions possess tremendous advantages over the classical multistep reaction sequences, as they avoid purification of the intermediates and circumvent time consuming protection/deprotection steps and functional group interconversions. In addition, the operational simplicity, the mild reaction conditions, and the ability of the same catalysts to promote several different transformations with remarkable selectivities constitute further noteworthy features of the organocatalyzed domino reactions. The great potential of organocatalyzed domino reactions is proven in the synthesis of a wide variety of cyclic compounds which are of interest for the synthesis of natural products and biologically active compounds.

Original languageEnglish (US)
Title of host publicationSynthetic Methods V - Organocatalysis
PublisherElsevier Ltd
Number of pages29
ISBN (Print)9780080951683
StatePublished - Sep 2012
Externally publishedYes


  • Bioinspired cascade reactions
  • Biologically active compounds
  • Natural products
  • Organocatalysis

ASJC Scopus subject areas

  • General Chemistry


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