3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth

H. Perfahl; H. M. Byrne; T. Chen; V. Estrella; T. Alarcón; A. Lapin; R. A. Gatenby; R. J. Gillies; M. C. Lloyd; P. K. Maini; M. Reuss; M. R. Owen

doi:10.1007/978-1-4614-4376-6_3

3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth

H. Perfahl, H. M. Byrne, T. Chen, V. Estrella, T. Alarcón, A. Lapin, R. A. Gatenby, R. J. Gillies, M. C. Lloyd, P. K. Maini, M. Reuss, M. R. Owen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.

Original language	English (US)
Title of host publication	Micro and Nano Flow Systems for Bioanalysis
Publisher	Springer Nature
Pages	29-48
Number of pages	20
ISBN (Print)	9781461443759
DOIs	https://doi.org/10.1007/978-1-4614-4376-6_3
State	Published - Nov 1 2012
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-C1-1013-04
Acknowledgements: HMB, MRO and HP acknowledge financial support by the Marie CurieNetwork MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partialsupport from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—FundingInitiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work wasfunded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication wasbased on work supported in part by Award No. KUK-C1-1013-04, made by King AbdullahUniversity of Science and Technology (KAUST).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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10.1007/978-1-4614-4376-6_3

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title = "3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth",

abstract = "We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.",

author = "H. Perfahl and Byrne, {H. M.} and T. Chen and V. Estrella and T. Alarc{\'o}n and A. Lapin and Gatenby, {R. A.} and Gillies, {R. J.} and Lloyd, {M. C.} and Maini, {P. K.} and M. Reuss and Owen, {M. R.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-C1-1013-04 Acknowledgements: HMB, MRO and HP acknowledge financial support by the Marie CurieNetwork MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partialsupport from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—FundingInitiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work wasfunded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication wasbased on work supported in part by Award No. KUK-C1-1013-04, made by King AbdullahUniversity of Science and Technology (KAUST). This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2012",

month = nov,

day = "1",

doi = "10.1007/978-1-4614-4376-6_3",

language = "English (US)",

isbn = "9781461443759",

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AU - Perfahl, H.

AU - Byrne, H. M.

AU - Chen, T.

AU - Estrella, V.

AU - Alarcón, T.

AU - Lapin, A.

AU - Gatenby, R. A.

AU - Gillies, R. J.

AU - Lloyd, M. C.

AU - Maini, P. K.

AU - Reuss, M.

AU - Owen, M. R.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-C1-1013-04 Acknowledgements: HMB, MRO and HP acknowledge financial support by the Marie CurieNetwork MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partialsupport from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—FundingInitiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work wasfunded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication wasbased on work supported in part by Award No. KUK-C1-1013-04, made by King AbdullahUniversity of Science and Technology (KAUST). This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.

AB - We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.

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U2 - 10.1007/978-1-4614-4376-6_3

DO - 10.1007/978-1-4614-4376-6_3

M3 - Chapter

SN - 9781461443759

SP - 29

EP - 48

BT - Micro and Nano Flow Systems for Bioanalysis

PB - Springer Nature

ER -

3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth

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