β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability

Yogesh R Mahajan; Magnus Rueping; Dieter Seebach

β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability

Yogesh R Mahajan, Magnus Rueping, Dieter Seebach

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

b3-Homoarginine was synthesized to examine the effect of arginine side chains on b-peptides. CD spectra revealed the presence of a 314-helix in MeOH, which undergoes a transition to an unordered or less ordered conformation in aq. soln. The dispersion of the amide and side-chain NH protons was increased when moving from MeOH to a 3:1 MeOH/H2O mixt. b-Heptaarginine was obsd. to be capable of penetrating the cells and entering the nuclear compartments. [on SciFinder (R)]

Original language	English (US)
Title of host publication	β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability
Place of Publication	Laboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz
Number of pages	2
State	Published - 2002
Externally published	Yes

Publication series

Name	Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002

Keywords

ABILITY
AMIDE
CELL
CELLS
CHAIN
CHAINS
CONFORMATION
Cd Spectra
Chemical
PROTEIN
SPECTRA
Structure
homoarginine beta peptide prepn heptaarginine cell

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Cite this

Mahajan, Y. R., Rueping, M., & Seebach, D. (2002). β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. In β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability (Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002).. http://www.mendeley.com/research/bhomoargininecontaining-bpeptides-structure-cellpenetrating-ability

Mahajan, Yogesh R ; Rueping, Magnus ; Seebach, Dieter. / β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. Laboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz, 2002. (Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002).

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title = "β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability",

abstract = "b3-Homoarginine was synthesized to examine the effect of arginine side chains on b-peptides. CD spectra revealed the presence of a 314-helix in MeOH, which undergoes a transition to an unordered or less ordered conformation in aq. soln. The dispersion of the amide and side-chain NH protons was increased when moving from MeOH to a 3:1 MeOH/H2O mixt. b-Heptaarginine was obsd. to be capable of penetrating the cells and entering the nuclear compartments. [on SciFinder (R)]",

keywords = "ABILITY, AMIDE, CELL, CELLS, CHAIN, CHAINS, CONFORMATION, Cd Spectra, Chemical, PROTEIN, SPECTRA, Structure, homoarginine beta peptide prepn heptaarginine cell",

author = "Mahajan, {Yogesh R} and Magnus Rueping and Dieter Seebach",

year = "2002",

language = "English (US)",

series = "Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002",

booktitle = "β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability",

}

Mahajan, YR, Rueping, M & Seebach, D 2002, β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. in β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002, Laboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz. <http://www.mendeley.com/research/bhomoargininecontaining-bpeptides-structure-cellpenetrating-ability>

β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. / Mahajan, Yogesh R; Rueping, Magnus; Seebach, Dieter.
β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. Laboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz, 2002. (Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability

AU - Mahajan, Yogesh R

AU - Rueping, Magnus

AU - Seebach, Dieter

PY - 2002

Y1 - 2002

N2 - b3-Homoarginine was synthesized to examine the effect of arginine side chains on b-peptides. CD spectra revealed the presence of a 314-helix in MeOH, which undergoes a transition to an unordered or less ordered conformation in aq. soln. The dispersion of the amide and side-chain NH protons was increased when moving from MeOH to a 3:1 MeOH/H2O mixt. b-Heptaarginine was obsd. to be capable of penetrating the cells and entering the nuclear compartments. [on SciFinder (R)]

AB - b3-Homoarginine was synthesized to examine the effect of arginine side chains on b-peptides. CD spectra revealed the presence of a 314-helix in MeOH, which undergoes a transition to an unordered or less ordered conformation in aq. soln. The dispersion of the amide and side-chain NH protons was increased when moving from MeOH to a 3:1 MeOH/H2O mixt. b-Heptaarginine was obsd. to be capable of penetrating the cells and entering the nuclear compartments. [on SciFinder (R)]

KW - ABILITY

KW - AMIDE

KW - CELL

KW - CELLS

KW - CHAIN

KW - CHAINS

KW - CONFORMATION

KW - Cd Spectra

KW - Chemical

KW - PROTEIN

KW - SPECTRA

KW - Structure

KW - homoarginine beta peptide prepn heptaarginine cell

M3 - Conference contribution

T3 - Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002

BT - β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability

CY - Laboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz

ER -

Mahajan YR, Rueping M, Seebach D. β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. In β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability. Laboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz. 2002. (Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002).

β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability

Abstract

Publication series

Keywords

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