Research output per year
Research output per year
Personal profile
Research Overview
Dr. Muhammad has broad interests in various epigenetic regulatory systems such as Polycomb group proteins (PcG), noncoding RNAs (ncRNA), nuclear RNAi, and histone marks. He obtained Ph.D., from the University of Strasbourg, where he studied the role of histone variant (CENP-A) in epigenetic specification of centromeres. Dr. Muhammad continued his postdoctoral work at the IGBMC, where he studied the role of CENP-A modifications in cell division. Currently in KAUST, he is focusing on different projects like:
- To understand the role of ncRNAs in epigenetic regulation and chromatin organization
- To uncover the function of chromatin associated RNAi machinery in mammalian cells
- To explore the link between gene regulation and proteins that write, read and erase histone marks in normal development versus stress condition.
Key Research Areas
Gene expression regulation, ncRNA, Chromatin associated RNA.
Education
Molecular and Cellular Biology, Ph.D. , Université de Strasbourg
2012
Biotechnology, B.S., University of Malakand
2006
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Research output
- 9 Article
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SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load
Mourier, T., Shuaib, M., Hala, S., Mfarrej, S., Alofi, F., Naeem, R., Alsomali, A., Jorgensen, D., Subudhi, A. K., Ben Rached, F., Guan, Q., Salunke, R. P., Ooi, A., Esau, L., Douvropoulou, O., Nugmanova, R., Perumal, S., Zhang, H., Rajan, I., Al-Omari, A., & 16 others, Dec 2022, In: Nature Communications. 13, 1, 601.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Ago1 controls myogenic differentiation by regulating eRNA-mediated CBP-guided epigenome reprogramming
Fallatah, B., Shuaib, M., Adroub, S., Paytuví-Gallart, A., Della Valle, F., Nadeef, S. S., Lanzuolo, C. & Orlando, V., Nov 2021, In: Cell Reports. 37, 9, p. 110066Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors
Guo, K., Wustoni, S., Koklu, A., Díaz-Galicia, E., Moser, M., Hama, A., Alqahtani, A. A., Ahmad, A. N., Alhamlan, F. S., Shuaib, M., Pain, A., McCulloch, I., Arold, S. T., Grunberg, R. & Inal, S., May 24 2021, In: Nature Biomedical Engineering.Research output: Contribution to journal › Article › peer-review
121 Scopus citations -
Nuclear AGO1 Regulates Gene Expression by Affecting Chromatin Architecture in Human Cells.
Shuaib, M., Parsi, K. M., Thimma, M., Adroub, S., Kawaji, H., Seridi, L., Ghosheh, Y., Fort, A., Fallatah, B., Ravasi, T., Carninci, P. & Orlando, V., Oct 21 2019, In: Cell systems. 9, 5, p. 446-458.e6 457999555 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells.
Liu, P., Shuaib, M., Zhang, H., Nadeef, S. & Liu, P., Dec 19 2019, In: Epigenetics & Chromatin. 12, 1Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function
Goutte-Gattat, D., Shuaib, M., Ouararhni, K., Gautier, T., Skoufias, D. A., Hamiche, A. & Dimitrov, S., May 21 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8579-8584 6 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Chaperoning the histone H3 family
Hamiche, A. & Shuaib, M., Mar 1 2012, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1819, 3-4, p. 230-237 8 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres
Shuaib, M., Ouararhni, K., Dimitrov, S. & Hamiche, A., Jan 26 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 4, p. 1349-1354 6 p.Research output: Contribution to journal › Article › peer-review
147 Scopus citations
Press/Media
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Disease severity linked to N protein of SARS-CoV-2
05/27/22
1 item of Media coverage
Press/Media: Press / Media
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COVID-19 Disease Severity Linked to N Protein of SARS-CoV-2 Virus
Huoming Zhang, Luke Esau, Muhammad Shuaib, Amit Subudhi & Arnab Pain
04/4/22
1 item of Media coverage
Press/Media: Press / Media
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SARS-CoV-2 Protein N-Related Disease Severity
03/29/22
1 item of Media coverage
Press/Media: Press / Media
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Disease severity linked to N protein of SARS-CoV-2
03/27/22 → 03/28/22
7 items of Media coverage
Press/Media: Press / Media
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New Biosensor Technology Makes Coronavirus Testing Quick and Easy
Muhammad Shuaib, Iain Mcculloch, Sahika Inal, Shofarul Wustoni, Arnab Pain, Stefan Arold & Keying Guo
05/28/21
1 item of Media coverage
Press/Media: Press / Media