Research output per year
Research output per year
Personal profile
Research Overview
Dr. Fiumelli’s research team applies a variety of cellular and molecular biology tools, transcriptomics, imaging of ion and metabolite dynamics as well as electrophysiology patch-clamp recordings to study the cellular and molecular bases of metabolic and signaling coupling between astrocytes and neurons. Much of our effort is focused on understanding the role of aerobically-derived lactate produced by astrocytes on the plasticity of neuronal networks and on the neuroprotection of neurons in physiological and neurodegenerative conditions.
Key Research Areas
Synaptic plasticity, Brain energy metabolism, Neuro-glial interaction, NMDA receptors, Aerobic glycolysis, Neocortical development.
Education
Biochemistry, M.S., University of Geneva
Biology, Ph.D. , University of Lausanne
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Research output
- 30 Article
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Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing
Nikiforidis, G., Wustoni, S., Routier, C., Hama, A., Koklu, A., Saleh, A., Steiner, N., Druet, V., Fiumelli, H. & Inal, S., Aug 21 2020, In: Macromolecular Bioscience. p. 2000215Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Gut microbiota modulates expression of genes involved in the astrocyte-neuron lactate shuttle in the hippocampus.
Margineanu, M. B., Sherwin, E., Golubeva, A., Peterson, V., Hoban, A., Fiumelli, H., Rea, K., Cryan, J. F. & Magistretti, P. J., Nov 16 2020, In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Gangliosides: Treatment Avenues in Neurodegenerative Disease.
Magistretti, P. J., Geisler, F. H., Schneider, J. S., Li, P. A., Fiumelli, H. & Sipione, S., Aug 6 2019, In: Frontiers in Neurology. 10, JULResearch output: Contribution to journal › Article › peer-review
59 Scopus citations -
Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling.
Tauffenberger, A., Fiumelli, H., Almustafa, S. & Magistretti, P. J., Sep 10 2019, In: Cell death & disease. 10, 9Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Lactate enhances NMDA receptor responses via two distinct mechanisms
Herrera-Lopez, G., Lemtiri-Chlieh, F., Mahmood, H. S., Mottier, L., Fiumelli, H. & Magistretti, P. J., Sep 2019, In: IBRO Reports. 6, p. S397-S398 1 p.Research output: Contribution to journal › Article › peer-review
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Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex
Virtanen, M. A., Lacoh, C. M., Fiumelli, H., Kosel, M., Tyagarajan, S., de Roo, M. & Vutskits, L., Jan 10 2018, In: Brain Structure and Function. 223, 4, p. 1999-2012 14 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Improving the Compatibility of Diketopyrrolopyrrole (DPP) Semiconducting Polymers for Biological Interfacing by Lysine Attachment
du, W., ohayon, D., Combe, C., Mottier, L., Maria, I. P., Ashraf, R., Fiumelli, H., Inal, S. & McCulloch, I., Aug 17 2018, In: Chemistry of Materials. 30, 17, p. 6164-6172 9 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
L-Lactate Regulates the Expression of Synaptic Plasticity and Neuroprotection Genes in Cortical Neurons: A Transcriptome Analysis
Margineanu, M. B., Mahmood, H., Fiumelli, H. & Magistretti, P. J., Oct 10 2018, In: Frontiers in Molecular Neuroscience. 11, 375.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations