Bruno Reversade

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Research Overview

Prof. Bruno REVERSADE is a human geneticist. By identifying mutations responsible for monogenic traits (that may be deleterious or beneficial), his teams have pioneered a paradigm shift in the field of Mendelian genetics. By pinpointing the subverted biological pathways which not only underlie the etiology of unique inherited conditions, Bruno's work has revealed biological nodes whose perturbation contributes to common maladies. This concept of "rare begets common" highlights how the study of humans with extreme phenotypes can foster innovation in therapies for common unmet medical needs. This "bedside to bench and back" paradigm has been realized for a wide array of conditions affecting metabolism, immunity, birth defects, infectious diseases or oncology indications. Bruno's work is characterized by its unusual breadth and depth whose foundations rely on mechanism-based investigations. The team employs patient-derived organoids, animal models and biochemical/structural assays to derive meaningful insights into the origin of each condition studied. Several of these discoveries have been licensed or are being developed for diagnostics and therapeutics purposes. Prof. Bruno REVERSADE was the inaugural A*STAR Investigator (Singapore), a fellow of the Branco Weiss Foundation (Switzerland), the first EMBO YIP established outside Europe, a senior Investigator of the National Research Foundation (Singapore), the inaugural AAA fellow and Professor at the University of Amsterdam (Netherlands), a distinguished visiting Professor at Koç University (Türkiye) and adjunct Professor at NUS (Singapore). For more information please visit:

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Molecular & Cellular Biology of Development, Ph.D., Sorbonne Université


M.S., Institut Pasteur de Madagascar



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