Research output per year
Research output per year
Personal profile
Research Interests
Dr. De Biasio's research interests revolve on the structural biology of human DNA replication and repair. His work makes use of cryogenic Electron Microscopy (cryo-EM) to obtain near-atomic resolution information on key enzymes operating in the human replisome, such as DNA polymerases. This structural data is combined with biochemical assays for a thorough understanding of the involved biomolecular processes.
Education
Ph.D., International Centre for Genetic Engineering and Biotechnology
2008
Chemistry, M.Sc., Department of Statistical sciences, University of Padova, Padova, Italy
2001
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Collaborations and top research areas from the last five years
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Author Correction: Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing (Nature Communications, (2022), 13, 1, (7833), 10.1038/s41467-022-35475-z)
Blair, K., Tehseen, M., Raducanu, V. S., Shahid, T., Lancey, C., Rashid, F., Crehuet, R., Hamdan, S. M. & De Biasio, A., Dec 2023, In: Nature Communications. 14, 1, 158.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
DNA replication of the lagging strand
Mindek, P., Klein, T. & De Biasio, A., Jul 27 2023, Proceedings of the Special Interest Group on Computer Graphics and Interactive Techniques Conference: Electronic Theater. ACMResearch output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Functional hierarchy of PCNA-interacting motifs in DNA processing enzymes
Hamdan, S. & De Biasio, A., Apr 11 2023, In: BioEssays.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Cryo-electron structures of the extreme thermostable enzymes Sulfur Oxygenase Reductase and Lumazine Synthase
Sobhy, M. A., Zhao, L., Anjum, D., Behzad, A., Takahashi, M., Tehseen, M., De Biasio, A., Sougrat, R. & Hamdan, S., Oct 2022, In: PloS one. 17, 10 October, e0275487.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing
Blair, K., Tehseen, M., Raducanu, V. S., Shahid, T., Lancey, C., Rashid, F., Creuhet, R., Hamdan, S. M. & De Biasio, A., Dec 2022, In: Nature Communications. 13, 1, 7833.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics
Raducanu, V.-S., Tehseen, M., Al-Amodi, A., Joudeh, L., De Biasio, A. & Hamdan, S., Nov 15 2022, In: Nature Communications. 13, 1Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Reply to: “Does PCNA diffusion on DNA follow a rotation-coupled translation mechanism?”
De March, M., Onesti, S. & De Biasio, A., Dec 1 2020, In: Nature Communications. 11, 1Research output: Contribution to journal › Article › peer-review
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Double Monoubiquitination Modifies the Molecular Recognition Properties of p15PAF Promoting Binding to the Reader Module of Dnmt1
González-Magaña, A., De Opakua, A. I., Merino, N., Monteiro, H., Diercks, T., Murciano-Calles, J., Luque, I., Bernadó, P., Cordeiro, T. N., Biasio, A. D. & Blanco, F. J., Oct 18 2019, In: ACS Chemical Biology. 14, 10, p. 2315-2326 12 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations
Press/Media
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New Findings in Enzymes and Coenzymes Described from King Abdullah University of Science and Technology (KAUST) (Structure of Aquifex aeolicus lumazine synthase by cryo-electron microscopy to 1.42 A resolution)
Hamdan, S., Sobhy, M. A. & De Biasio, A.
09/13/24
1 item of Media coverage
Press/Media: Press / Media
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King Abdullah University of Science and Technology (KAUST) Reports Findings in Severe Combined Immunodeficiency (Severe Combined Immunodeficiency from a Homozygous DNA Ligase 1 Mutant with Reduced Catalytic Activity but Increased Ligation ...)
Hamdan, S., Merzaban, J., Tehseen, M. & De Biasio, A.
06/27/24
1 item of Media coverage
Press/Media: Press / Media
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Resuelven la estructura de las polimerasas que aseguran la estabilidad de los genes en la multiplicación celular
Hamdan, S., Takahashi, M., Sobhy, M. A., Tehseen, M. & De Biasio, A.
01/6/24
1 item of Media coverage
Press/Media: Press / Media
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Study reveals dynamics of DNA ligation during genome replication
01/24/23
2 items of Media coverage
Press/Media: Press / Media
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DNA replication under the microscope
Hamdan, S., Tehseen, M. & De Biasio, A.
11/22/21
1 item of Media coverage
Press/Media: Press / Media
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Resuelven la estructura de las polimerasas que aseguran la estabilidad de los genes en la multiplicación celular
Hamdan, S., Takahashi, M., Sobhy, M. A., Tehseen, M. & De Biasio, A.
10/28/21
1 item of Media coverage
Press/Media: Press / Media